Dipeptidyl Peptidase IV or DPP-IV is a critical enzyme that regulates a wide variety of physiological processes including eating, digestion, immune function, pain perception, growth, infection, and many others. This enzyme which is present in all organs and the blood starts or stops these processes by removing a two amino acid peptide from a variety of peptides and proteins from the free amino end of these molecules. Thus, growth hormone releasing factor (GHRF), which is secreted by the hypothalamus, stimulates the pituitary gland to release growth hormone until DPP-IV removes two amino acids from GHRF to inactivate it. Substance P, a nine amino acid peptide, mediates the perception of pain when released from injured tissue and continues to provoke pain until DPP-IV removes two amino acids from substance P, terminating the pain perception.
Click here to view a sample report.
This test requires a blood draw.